A Retrospective Cohort Study of Physical Activity and Survival in Patients Treated with Immune Checkpoint Inhibitors.

ABSTRACT:

Background

The impact of physical activity in patients with cancer treated with immune checkpoint inhibitors (ICI), both of which affect outcomes via modulating the immune system, is unclear. We investigated associations between self-reported, pretreatment physical activity and survival in a series of patients with cancer treated with ICI.

Methods

This retrospective cohort study included 930 patients treated with ICI who previously reported physical activity and had good performance status at treatment initiation. Hazards of death associated with increasing quartile of physical activity, measured as weekly metabolic equivalent of task minutes derived from the International Physical Activity Questionnaire (IPAQ), were estimated by multivariable Cox proportional hazards models

SUBMITTER: Parker NH 

PROVIDER: S-EPMC12579459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature