Tissue-specific co-expression patterns of BAF complex genes across human endocrine and non-endocrine tissues.

ABSTRACT:

Abstract

BRG1/BRM-associated factor (BAF) chromatin remodeling complexes are essential for normal endocrine function and are implicated in various metabolic and developmental disorders. However, the full range of chromatin-based regulatory programs and their molecular configurations in endocrine development remains unclear. In this study, we developed a computational pipeline to analyze bulk RNA-seq data from 45 human tissues and constructed tissue-specific co-expression networks for 30 core BAF complex genes. Using co-expression network analysis and Louvain clustering, we identified co-expression patterns that formed coherent gene communities for each tissue, comprising different combinations of 46 curated BAF subcomplex genes. In metabolically active non-endocrine tissues (kidney

SUBMITTER: Dong X 

PROVIDER: S-EPMC12579490 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature