Surface-Engineered Mitochondria with Targeting Potential for Endothelial Repair.

ABSTRACT:

Purpose

Mitochondrial dysfunction contributes to endothelial injury in vascular diseases and interventions. While mitochondrial transplantation offers a promising therapeutic strategy, current approaches lack target specificity, efficient uptake, and long-term retention. This study presents a surface-engineering approach to enhance mitochondria delivery to the vascular endothelium as a step toward novel endothelial repair strategies.

Methods

Mitochondria were isolated from healthy induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs) and surface functionalized with a phospholipid-based coating platform (DSPE-PEG) to enable peptide functionalization. DSPE-PEG was conjugated to either VCAM-1-binding peptide and collagen-binding peptide to enable targeting to

SUBMITTER: Applewhite B 

PROVIDER: S-EPMC12579636 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature