Altered tyrosine metabolism and B lymphocyte profiles are associated with disease severity in pediatric anti-NMDAR encephalitis: a cross-sectional study.

ABSTRACT: The serum phenylalanine (Phe)/tyrosine (Tyr) ratio has recently been described as a potential prognostic biomarker for anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in adulthood; however, little is known about this phenomenon among children. As such, this study aimed to identify the characteristics of Phe and Tyr metabolism and specific immune cell subsets in children diagnosed with anti-NMDAR encephalitis. Clinical data from 24 patients diagnosed with anti-NMDAR encephalitis at the Capital Center for Children's Health, Capital Medical University, between January 2019 and March 2022, were retrospectively analyzed. Among children with anti-NMDAR encephalitis, blood levels of Tyr were decreased in those with sleep disorders and decreased consciousness. Blood Tyr levels and Phe/Tyr

SUBMITTER: Cao D 

PROVIDER: S-EPMC12579682 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature