Epidemiology, treatment patterns and effectiveness of adherence to Bacillus Calmette-Guerin therapy in intermediate and high-risk non-muscle-invasive bladder cancer patients: a retrospective cohort analysis using German health claims data.

ABSTRACT:

Purpose

To assess the epidemiology, treatment patterns, and Bacillus Calmette-Guérin (BCG) instillations in Non-Muscle-Invasive Bladder Cancer (NMIBC) patients to evaluate guidelines compliance and effectiveness of adherence on real-world outcomes.

Methods

NMIBC patients with BCG-treatment were identified in a retrospective cohort study using German health claims data. The first BCG prescription was defined as index date. Crude and standardized annual incidence were calculated. Subsequent treatment regimens were described based on prescriptions to assess adherence. BCG-maintenance adherents were compared with non-adherents using a landmark time approach and Cox proportional hazard model.

Results

The annual standardized incidence per 100,000 for intermediate- and high-

SUBMITTER: Luna J 

PROVIDER: S-EPMC12579700 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature