Associations Between Anxiety or Depression Diagnosis and Immune Checkpoint Inhibitor Outcomes.

ABSTRACT:

Introduction

Anxiety and depression can affect immune function, yet little is known about their impact on immune checkpoint inhibitor (ICI) therapy outcomes. We investigated associations between an existing anxiety or depression diagnosis and ICI outcomes.

Methods

In this secondary analysis, multicenter retrospective real-world data were abstracted from medical charts. Patients included received ≥ 1 dose of anti-PD-1 or anti-PD-L1 monotherapy. Key variables abstracted were anxiety/depression diagnosis at treatment initiation, ICI therapy outcomes (immune-related adverse events, irAEs; overall survival, OS; time to treatment failure, TTF), and other sociodemographic and clinical factors.

Results

Of the 913 patients, 11% and 12% had an existing anxiety or depression dia

SUBMITTER: Derry-Vick H 

PROVIDER: S-EPMC12579804 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature