Dendrobine alleviates CCl₄-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways.

ABSTRACT:

Background

Acute liver injury (ALI) represents a critical clinical challenge characterized by rapid degradation of hepatic function, necessitating prompt intervention for improved patient outcomes. Dendrobine (DDB) is the main bioactive component of Dendrobium nobile Lindl. (DNL), a traditional Chinese herb renowned for its protective effects against liver injury. However, the specific mechanisms underlying its hepatoprotective effects have not yet been fully elucidated.

Objective

This study aims to elucidate the potential mechanism underlying the protective effects of DDB against ALI, particularly through the Nrf2/PPARγ/SOD2 pathways, to provide a scientific basis for its application in ALI treatment.

Methods

CCl₄-induced ALI models in animals were used to

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12579814 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature