Prognostic Implications of Thrombocytopenia in Chinese Patients With Newly Diagnosed Multiple Myeloma.

ABSTRACT:

Background

Thrombocytopenia is less common but shows high risk of early mortality in newly diagnosed multiple myeloma (NDMM) patients. In the era of novel agents-based induction therapy (NAIT), it is unclear whether NAIT can overcome the poor prognosis associated with thrombocytopenia.

Objectives

To evaluate the prognostic implications of thrombocytopenia in NDMM patients.

Methods

We retrospectively analyzed 1363 NDMM patients baseline characteristics, treatment response and survival, further performed regression analysis, constructed a nomogram model to predict progression free survival (PFS), and further internally validated this model.

Results

Overall, 211 (15.48%) NDMM patients were harboring thrombocytopenia, with advanced disease stages and worse outcomes

SUBMITTER: Li X 

PROVIDER: S-EPMC12579819 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature