Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

ABSTRACT:

Introduction

Recent advancements in risk stratification have greatly improved outcomes in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Despite favorable prognostic indicators, including the absence of cytogenetic abnormalities and minimal residual disease (MRD) negativity, relapse remains a major clinical concern.

Methods and results

We investigated the clinical significance of immunoglobulin heavy chain (IGH) clonality using RNA sequencing data in BCP-ALL. We analyzed IGH clonality from 136 patients. IGH abundance followed a power law distribution, which enabled us to identify disease clones as outliers based on read count. In total, 330 disease clones were detected, and patients were categorized into three clonotype groups: undetectable disease clone

SUBMITTER: Katai Y 

PROVIDER: S-EPMC12579820 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature