Phosphorylation of VAMP3 couples IL-6 exocytosis to dendritic cell activation.

ABSTRACT: Adaptive immunity is crucial for combating pathogens and generating immunological memory. Central to adaptive immunity are myeloid cells, which activate upon pathogen detection. Activation is essential for inflammatory cytokine release and requires a complex series of molecular events to facilitate cytokine expression. However, although the transcriptional machinery regulating cytokine expression is well defined, it is apparent that trafficking machinery also has to be reprogrammed to facilitate cytokine secretion. We demonstrate through quantitative total internal resonance fluorescence (TIRF) microscopy that short-term inflammatory stimulation with lipopolysaccharide (LPS) is sufficient to upregulate interleukin-6 (IL-6) secretion in dendritic cells. Through bioinformatic analysis of pho

SUBMITTER: Chen T 

PROVIDER: S-EPMC12579954 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature