The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.

ABSTRACT: The olfactory bulb (OB) contains multiple parallel projection neurons to relay the nature of a stimulus. In a mouse ex vivo slice preparation, we used patch-clamp electrophysiology to measure intrinsic properties, excitability, action potential (AP) shape, voltage-activated conductances and neuromodulation in the newly categorized superficial tufted cells (sTCs) compared with those of mitral cells (MCs). We propose that a marked difference in voltage-dependent current represents distinct ion channel populations that affect the kinetics of action potentials and evokes an increase in sTC firing frequency, despite both types of projection neurons having similar AP spiking activity. Triple-colored immunofluorescence and RNA scope were used to detect colocalization of the Kv1.3 ion channel and

SUBMITTER: Kolling LJ 

PROVIDER: S-EPMC12579955 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature