Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study.

ABSTRACT:

Background and aims

Observational studies show that women with hypertensive disorders of pregnancy have greater risk of cardiovascular disease later in life. Whether these associations reflect causal pathways is uncertain. This study used genetic epidemiology to explore the causal relevance of preeclampsia and gestational hypertension on cardiovascular disease.

Methods

Two-sample Mendelian randomization (MR) analyses were conducted using summary-level data from FinnGen and from the to date largest consortia for each outcome. One-sample MR analyses were performed using individual-level data from 202 876 White British women from the UK Biobank. Genetic instruments for preeclampsia and gestational hypertension were from the most updated genome-wide association study (n = 20 064

SUBMITTER: Taageby Nielsen S 

PROVIDER: S-EPMC12579974 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature