Diagnostic value of integrating salivary and blood miRNAs for pancreatic cancer detection.

ABSTRACT:

Background

Pancreatic cancer remains one of the most lethal malignancies due to its late-stage diagnosis and limited treatment options. Conventional diagnostic methods, such as imaging and tissue biopsy, often lack sensitivity in early-stage detection and are invasive, limiting their widespread application. There is an urgent need for non-invasive, highly accurate biomarkers to facilitate early diagnosis and improve patient outcomes. Circulating microRNAs (miRNAs) have emerged as promising liquid biopsy biomarkers, offering the potential for early detection through minimally invasive methods. This meta-analysis aims to evaluate the diagnostic performance of blood- and saliva-derived miRNAs in detecting pancreatic cancer.

Methods

A systematic search of PubMed, Web of Science,

SUBMITTER: Wilson P 

PROVIDER: S-EPMC12580116 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature