Remimazolam used for sedation during spinal anesthesia puncture provides faster sedation effect and increase recovery rate compared to midazolam: a randomized controlled trial.

ABSTRACT:

Background

Surgical time-out is essential for patient safety, requiring patients to remain conscious to verify their identity and surgical site. In China's high-volume operating rooms, this step is crucial to prevent errors. Spinal anesthesia often induces anxiety, making sedation necessary. An ideal sedative must provide effective anxiolysis while allowing rapid recovery. This study compares remimazolam and midazolam to meet these dual demands and assess their cardiorespiratory safety.

Methods

This prospective, randomized controlled trial compared remimazolam and midazolam for sedation in patients undergoing elective ultrasound-guided spinal anesthesia. Patients were assigned to receive either remimazolam (0.1 mg/kg bolus, 0.5-1.0 mg/kg/h infusion) or midazolam (0.07 mg/kg

SUBMITTER: Sun P 

PROVIDER: S-EPMC12580118 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature