Unexpected estradiol decline during ovarian stimulation monitoring affects cumulative live birth.

ABSTRACT:

Background

E₂ is important in follicular development. During monitoring of stimulated cycles, serum levels of E₂ are expected to increase steadily with follicle growth until final maturation. Unexpected E₂ decline before triggering is reported in monitored COS cycles, yet its clinical significance remains controversial.

Methods

The retrospective study was carried out in 27,487 conventional COS cycles at Xiamen University Affiliated Chenggong Hospital between January 2013 and December 2021. The occurrence of E₂ decline during the monitoring was defined as the observation of a lower E₂ value than the previous visit. Propensity matching and multivariate generalized linear models were used to analyze the association between

SUBMITTER: Chen H 

PROVIDER: S-EPMC12580126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature