Neutrophils from Alzheimer's disease mice fail to phagocytose debris and show altered release of immune modulators with age.

ABSTRACT: Recent reports show that neutrophil activity plays a role in the cognitive decline associated with Alzheimer's Disease (AD). There is evidence of altered functions in neutrophils isolated from AD patients. Whether these altered functions are inherent to the AD disease state is unknown. The goal of this study was to determine if neutrophil functions are altered in AD mice and if these changes occur only after symptoms appear. To address this hypothesis, we used a primary neuronal culture model, generated from 3xTg perinatal mice, since AD is considered a CNS disease. The 3xTg primary neuronal culture gradually increase the release of Aβ (40 and 42) as the culture ages. To assess neutrophil functions, neutrophils isolated from young male/female mice (3-6 months of age) or aged male/female mi

SUBMITTER: Kays M 

PROVIDER: S-EPMC12580139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature