The efficacy of lactic acid bacteria-based toothpaste on oral health: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Lactic acid bacteria (LAB) have emerged as promising adjunctive agents for oral health management due to their antimicrobial and immunomodulatory properties. With the increasing incorporation of probiotics into oral care products, it is critical to evaluate their clinical efficacy. This systematic review and meta-analysis aimed to assess the effectiveness of LAB-based toothpaste in improving oral health outcomes.

Methods

Following PRISMA guidelines, five databases (MEDLINE, EMBASE, Scopus, Web of Science, and CENTRAL) were searched through February 2025. Randomized controlled trials (RCTs) evaluating toothpastes containing probiotic, prebiotic, synbiotic, or postbiotic agents were included. Primary outcomes included plaque index (PI), gingival index (GI), bleedi

SUBMITTER: Choi EM 

PROVIDER: S-EPMC12580182 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature