Metagenomic analysis of blood microbiota alterations: insights into HIV progression and immune restoration.

ABSTRACT:

Introduction

Emerging evidence suggests that the blood microbiome may influence the progression of HIV infection and immune restoration. This study aims to comprehensively characterize blood microbiota alterations associated with HIV infection and antiretroviral therapy (ART), and to evaluate their potential as microbial indicators for assessing infection status and immune restoration.

Methods

We recruited 91 participants, including 31 treatment-naïve HIV-infected individuals, 30 ART-treated individuals with undetectable viral loads, and 30 healthy controls. Blood samples were collected for metagenomic sequencing and immunological profiling.

Results

HIV infection profoundly disrupted blood microbiota diversity and composition, with a marked reduction in α-diversity an

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12580212 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature