The role of the hippocampus and retrosplenial cortex in spatial memory: a double blind anodal transcranial direct current stimulation study.

ABSTRACT:

Introduction

Spatial memory supports orientation and navigation by integrating multiple spatial reference frames. Neuroimaging and lesion studies implicate the hippocampus (HIP) and retrosplenial cortex (RSC), but causal evidence from non-invasive brain stimulation is limited.

Methods

Eighteen participants performed a spatial localization task in a virtual room under three stimulation conditions: anodal transcranial direct current stimulation (tDCS) over the left RSC, anodal tDCS over the left HIP, and sham. Task conditions varied in reference frame (viewer-, object-, room-centered) and perspective shift (0°, 45°, 135°). Accuracy was analyzed with non-parametric statistics.

Results

Performance declined with increasing viewpoint rotation, especially in room-centered tr

SUBMITTER: De Biase R 

PROVIDER: S-EPMC12580218 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature