Cost-Effectiveness Analysis of Fecal Immunochemical Test- and Colonoscopy-based Colorectal Cancer Screening across Varying Uptake Rates.

ABSTRACT:

Objectives

To reduce the burden of colorectal cancer (CRC), identifying cost-effective screening strategies with particular attention to screening adherence is essential. We aimed to assess the cost-effectiveness of screening strategies using fecal immunochemical test (FIT) and/or total colonoscopy (TCS) through simulation model analyses using Japanese data, considering various uptake rates.

Methods

A state-transition Markov model was used to evaluate the cost-effectiveness of FIT-based, TCS-based, and combined FIT- and TCS-based screening strategies. Variable uptake rates for FIT (40%-80%), screening TCS (10%-80%), and TCS following a positive FIT (70%-90%) were assessed. Analyses were performed from the healthcare payer's perspective, evaluating direct medical costs and qu

SUBMITTER: Sekiguchi M 

PROVIDER: S-EPMC12580226 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature