A plasma miRNA signature, including miR-495, as early diagnostic biomarkers associated with cognitive decline in Alzheimer's disease.

ABSTRACT:

Introduction

A definitive diagnosis of Alzheimer's disease (AD) requires the identification of pathological changes. Plasma miRNAs have emerged as potential AD diagnostic biomarkers.

Methods

A matched case-control study was conducted using convenience sampling to evaluate the ability of candidate miRNAs in differentiating probable AD patients with mild cognitive impairment (MCI) or mild dementia (MD) stages. The initial sample included 29 patients and 58 controls. Plasma levels of miRNAs were measured by real-time polymerase chain reaction (RT-PCR) and their associations with scores from a comprehensive neuropsychological battery of cognitive tests analyzed by Spearman's correlation.

Results

A miR-181a, miR-181c, and miR-495 signature showed area-under-curve values in

SUBMITTER: Cots A 

PROVIDER: S-EPMC12580240 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature