The kinetics of CA125 levels as a prognostic marker for in-hospital mortality in patients with acute heart failure: a pilot study.

ABSTRACT:

Background

Acute heart failure (AHF) carries a high risk of in-hospital mortality, and identifying reliable prognostic biomarkers remains challenging. Cancer antigen 125 (CA125) has recently emerged as a potential marker in heart failure, but its prognostic value for in-hospital mortality in AHF is unclear. This pilot study examined the kinetics of CA125 and its association with in-hospital mortality in AHF patients.

Methods

In this single-center prospective cohort study, 80 participants were enrolled and divided into three groups: AHF (n = 25), chronic heart failure (CHF, n = 31), and controls (n = 24). Serum CA125 was measured at admission and after 7 days. The primary endpoint was in-hospital mortality.

Results

CA125 levels were significantly h

SUBMITTER: Nguyen Ngoc Dang H 

PROVIDER: S-EPMC12580267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature