Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective.

ABSTRACT:

Background

Preeclampsia (PE), a leading cause of maternal and fetal morbidity, remains poorly understood mechanistically. While metal elements like manganese (Mn) are critical for placental function, their interplay with gut microbiota in PE pathogenesis is underexplored. This study evaluates placental heavy metal exposure-particularly Mn-and its interaction with gut microbiota in modulating PE risk.

Methods

The study included 21 healthy pregnant women (Control group), and 21 pregnant women diagnosed with PE (PE group). Placental samples were collected to measure metal elements concentrations, while fecal samples were obtained to assess gut microbiota composition. Associations between gut microbiota, PE, and placental Mn levels were analyzed using the Analysis of Composition

SUBMITTER: Ding T 

PROVIDER: S-EPMC12580270 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature