Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.

ABSTRACT:

Objectives

To present the most up-to-date systematic review and meta-analysis assessing the relationship between the neutrophil-to-lymphocyte ratio (NLR) and mortality in individuals diagnosed with sepsis.

Methods

We conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane Library until March, 2025 for studies which evaluated the link between NLR and the mortality of patients with sepsis. Odds ratios (OR) and 95% confidence intervals (CI) were used for data pooling. In addition, sensitivity analysis and subgroup analysis were performed to examine the stability of the results and potential sources of heterogeneity. All analyses were performed using Review Manager 5.4 and STATA 15.1.

Results

A total of 21 studies including 23,621 pati

SUBMITTER: Gao Z 

PROVIDER: S-EPMC12580286 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature