Ultrastructure of human platelet concentrates after treatment with pathogen reduction technologies for prolonged storage.

ABSTRACT:

Background and objectives

Pathogen reduction technologies (PRTs) increase blood supply safety but may also increase platelet storage lesion, probably due to mitochondrial DNA damage. The purpose of this study was to investigate whether these changes are morphologically detectable.

Materials and methods

Blood platelets were obtained by triple-dose apheresis collection (n = 8). Immediately after splitting, single units were left untreated (CONTROL) or treated with either psoralen-UVA (INTERCEPT) or riboflavin-UVB (MIRASOL). All platelet units were resuspended in platelet additive solution (INTERSOL or SSP+) and stored for up to seven days. Seven samples from each donation were examined by electron microscopy fresh, i.e., immediately after collection, and after1 day and

SUBMITTER: Barham M 

PROVIDER: S-EPMC12580302 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature