Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.

ABSTRACT:

Introduction

The development of a rapid and affordable assay to screen participants for Q12 additional testing could streamline TB screening in resource-limited settings and for community-wide health screens. Sputum remains the primary testing sample, making it potentially ideal for a screening testing. Neutrophils are highly expanded in sputum from individuals with pulmonary TB with high specificity and have potential as a biomarker for TB.

Methods

Three neutrophil associated proteins, neutrophil gelatinase associated-lipocalin (NGAL), the protein heterodimer S100A8/A9 and the protein death ligand-1 (PDL-1), were measured in presumptive TB cases from participants attending a primary healthcare clinic in Durban, South Africa, using commercially available ELISAs on a total of

SUBMITTER: Chambers M 

PROVIDER: S-EPMC12580308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature