The effects of amplitude modulated transcranial alternating current stimulation on working memory of college students.

ABSTRACT:

Background

Recent studies suggest that amplitude-modulated transcranial alternating current stimulation (AM-tACS) may enhance cognitive functions, but its mechanisms and optimal application remain unclear.

Methods

Thirty-three healthy university students were randomly assigned to Sham, tACS (40 Hz, 1 mA, bilateral prefrontal cortex), or AM-tACS (200 Hz carrier frequency) groups, in AM-tACS, the baseband modulation frequency was individualized based on the pre-task phase-locking value (PLV) derived from occipitofrontal EEG. Working memory (WM) was assessed via a delayed-match-to-sample task (accuracy and sensitivity index d').

Results

Compared to Sham, the tACS group showed significant WM accuracy improvement (p < 0.05). AM-tACS exhibited a smaller but statistic

SUBMITTER: Wang H 

PROVIDER: S-EPMC12580318 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature