<i>Enterococcus faecium</i> DNA in acute decompensated cirrhosis: a key player in inflammation and kidney dysfunction.

ABSTRACT: Liver cirrhosis is a major global health burden, with acute-on-chronic liver failure (ACLF) being a severe complication associated with high mortality. Systemic inflammation (SI) plays a crucial role in ACLF development, yet indicators for predicting disease progression remain limited. Enterococcus faecium (EF) has been implicated in bacterial translocation and SI, but its clinical relevance in ACLF remains unclear. We analyzed sera of 197 patients from a prospective observational study with acutely decompensated liver cirrhosis versus 234 healthy controls for the presence of EF DNA using RT-qPCR and cytokine analysis of serum samples. Overall, EF DNA was detected in 26% (n = 51, p = 0.001) of the patients, and only in 1.28% (n = 3, p = 0.001) in t

SUBMITTER: Tyc O 

PROVIDER: S-EPMC12580341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature