Enlarged perivascular spaces in the basal ganglia mediate the negative impact of HbA1c levels on mild cognitive impairment.

ABSTRACT:

Background

This study aimed to investigate the mediating effect of enlarged perivascular space (EPVS) in basal ganglia (BG) on the relationship between glycated hemoglobin (HbA1c) levels and mild cognitive impairment (MCI) in patients with cerebral small vessel disease (CSVD).

Methods

Data on HbA1c levels and MOCA scores and CSVD imaging markers, including EPVS volume and distribution patterns were collected. Logistic regression was performed to identify independent risk factors for MCI. A mediation effect analysis was further conducted to determine whether BG-EPVS mediate the impact of HbA1c on cognitive impairment.

Results

A total of 244 CSVD patients were enrolled in this study. Compared with non-DM patients, DM patients had a significantly greater BG-EPVS volume (

SUBMITTER: Liu C 

PROVIDER: S-EPMC12580363 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature