Risk factors for angiotensin converting enzyme inhibitor angioedema in a South African population.

ABSTRACT:

Introduction

Angiotensin converting enzyme inhibitors (ACEI) have proven mortality and morbidity benefit in hypertension, ischemic heart disease, heart failure, and renal disease and are among the most prescribed medications globally. ACEI angioedema (AE-ACEI) is a potentially life-threatening adverse drug reaction that is reported to occur more frequently in African American populations. However, the clinical profile of AE-ACEI is poorly characterized in diverse African populations.

Methods

A case-controlled cohort study with enrolment of AE-ACEI cases and drug-tolerant controls in Cape Town, South Africa. Univariable and multivariable analysis was performed. Controls were defined as patients tolerating ACEI for a minimum of two years. Cases were defined as patients who had

SUBMITTER: Day C 

PROVIDER: S-EPMC12580374 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature