The Pre-clinical Safety of Graphene-based Electrodes Implanted on Rat Cerebral Cortex.

ABSTRACT: Graphene has emerged as a promising nanomaterial for brain-computer interface (BCI) applications due to its excellent electrical properties and biocompatibility. However, its long-term structural compatibility on the cerebral cortex requires further validation. This study assessed both functional compatibility and preservation of neural tissue architecture for graphene/parylene C composite electrodes implanted on the rat cortical surface, in accordance with ISO 10993-6 guideline weekly neurobehavioral assessments and comprehensive histopathological analyses were conducted for four weeks post-implantation. Our results revealed no significant differences in neurobehavioral outcomes between graphene-based and medical-grade silicone implants. Histopathological examination showed no noticeable

SUBMITTER: Kim G 

PROVIDER: S-EPMC12580400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature