Tumor-infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naive to medical therapy.

ABSTRACT: Tumor-infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors and cytokines. In this study, we assessed the effect of SRLs treatment on TICs. A retrospective and observational study was performed on acromegaly patients to compare the number of TICs in 75 patients naïve to SRL before surgery and in 33 patients treated with SRL for at least 6 months before surgery. In SRLs-naive patients at surgery, the CD68+/CD8+ ratio was higher in invasive tumors (4.9, IQR: 14, p = .028) than in non-invasive tumors (4.3, IQR: 4.2) as well as in patients not responsive to post-surgical/adjuvant treatment with SRLs (7.5, IQR: 13, p = .

SUBMITTER: Chiloiro S 

PROVIDER: S-EPMC12580450 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature