Pediatric liver transplant outcomes: A comparative analysis of steatotic donor grafts.

ABSTRACT:

Objectives

Hepatic steatosis impacts the quality of grafts, affecting transplant outcomes. Rising obesity rates and subsequent donor graft steatosis further influence the organ shortage crisis in pediatric liver transplantation (LT). Our study aimed to evaluate how donor steatosis modulates the outcomes of pediatric LT.

Methods

We analyzed the United Network of Organ Sharing database for transplanted donor grafts from January 01, 2004, to April 30, 2024. We stratified pediatric (≤18 years) LT recipients into steatotic grafts, subdivided into <30% and ≥30%. Graft failure was assessed using Kaplan-Meier curves, and Cox proportional hazards models, with Lasso regression identifying key predictive variables. Gradient-boosting decision tree was used to assess the level of likelih

SUBMITTER: Anouti A 

PROVIDER: S-EPMC12580464 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature