Adult Striatal Neurogenesis-A Comparative Approach Between Pigeons, Mice, Macaques, and Human.

ABSTRACT: Adult neurogenesis describes the formation of new neurons in the adult brain, a process that is fundamental to related functions, particularly in the hippocampus. Although studies reported adult striatal neurogenesis in humans, the phenomenon is still understudied in those regions. Thus, to gain a deeper understanding in different species, the expression of neurogenic markers was quantitatively analyzed in striatal subregions of pigeons and mice. Further, in macaques and human a detailed analysis of the subventricular zone (SVZ) was performed and the human caudate nucleus was qualitatively examined. The results show higher neuronal plasticity in striatal subregions of pigeons compared to mice, as reflected by higher numbers of Bromodeoxyuridine (BrdU)+, BrdU+/Doublecortin+, Doublecortin+,

SUBMITTER: Herold C 

PROVIDER: S-EPMC12580488 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature