Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver.

ABSTRACT: Interindividual variability in hepatic drug metabolism and transport is well-known, and genetic variation in pharmacogenes impacts the efficacy and safety of drug treatments. Recent reports have indicated that the minor allele of the nuclear transcription factor I/B (NFIB), rs28379954 T > C, affects the metabolism of risperidone and clozapine, which are mediated by CYP2D6 and CYP1A2, respectively. First, we reanalyzed the association between rs28379954 T > C and CYP2D6 activity in three independent cohorts exposed to CYP2D6 substrates (propafenone, tamoxifen, and sparteine) which revealed no association. Next, to investigate the effects of all four NFIs expressed in human livers more broadly, 150 well-characterized hepatic tissue samples, along with data on expression quantitative trait lo

SUBMITTER: Klein K 

PROVIDER: S-EPMC12580495 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature