Danggui Shaoyao San attenuates depressive-like behaviors in mice via TLR4/NF-κB p65/JAK-STAT3/AKT-GSK3β signaling pathways: modulation of hippocampal neurogenesis and neuroinflammation.

ABSTRACT:

Purpose

Danggui Shaoyao San (DSS), a traditional Chinese herbal formula abundantly containing both medicinal and dietary components, was first documented in Jin Gui Yao Lue (Synopsis of the Golden Chamber) by Zhang Zhongjing during the Eastern Han Dynasty of China. Depression, a multifactorially induced affective disorder, has its precise etiological factors and underlying pathophysiological mechanisms remaining incompletely understood. Therefore, this study aimed to investigate the therapeutic effects of DSS on corticosterone-induced depression in mice and clarify the underlying mechanisms.

Methods

The therapeutic effects of DSS on depressive-like behaviors were assessed via behavioral tests in mice. Potential therapeutic targets of DSS were explored via network pharmacolog

SUBMITTER: Tang CF 

PROVIDER: S-EPMC12580595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature