Associations between attenuated auditory p300 event-related potential and cognitive basic symptoms in young people at clinical high risk for psychosis.

ABSTRACT:

Aims

The value of assessing basic symptoms in clinical-high-risk for psychosis (CHR) is becoming increasingly apparent. Greater recognition of subjective experience in neuroscience and psychiatry has renewed research interest in electrophysiological biomarkers of basic symptoms. This study aims to investigate whether cognitive basic symptoms (COGDIS), which capture a subset of basic symptoms, are associated with P3b attenuation and the modulation of brain connectivity in a large sample of CHR.

Methods

Data from the North American Prodromal Longitudinal Study- 3 (NAPLS-3) comprised 440 male and female CHR individuals who completed both the COGDIS items of the schizophrenia proneness instrument as well as a two-tone auditory oddball task. P3b amplitude was measured at the cent

SUBMITTER: Martin JC 

PROVIDER: S-EPMC12580602 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature