Effect of Blood Purification on Early Response in Children With Hemophagocytic Lymphohistiocytosis.

ABSTRACT: To evaluate the impact of blood purification (BP) therapy on early treatment response and overall survival (OS) in paediatric haemophagocytic lymphohistiocytosis (HLH). We retrospectively reviewed HLH cases from 2012 to 2022, comparing outcomes among patients treated with the HLH-94/04 protocol, BP monotherapy, BP combined with HLH-94/04 (BP + HLH-94/04), or other regimens. A matched subgroup analysis was conducted in patients with multi-organ dysfunction syndrome (MODS) to assess survival differences. Cox regression identified prognostic factors, and mediation analysis evaluated the contribution of complete remission (CR) at 4 weeks to OS. A total of 102 patients were included, five with primary HLH. Among them, 53 received HLH-94/04, 13 received BP monotherapy, 22 received BP + HLH-94/04

SUBMITTER: Yu L 

PROVIDER: S-EPMC12580619 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature