Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell K_ATP channels.

ABSTRACT: ATP-sensitive potassium (K_ATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion. K_ATP channels are hetero-octameric complexes composed of four pore-forming subunits (Kir6.2, encoded by KCNJ11) and four regulatory subunits (SUR1, encoded by ABCC8). A multi-species alignment of the KCNJ11 gene revealed that, although the sequence is highly conserved, residue 39 varies among different mammals. Previous studies have shown that this residue plays a critical role in regulating K_ATP channel activity and its mutation results in neonatal diabetes in humans. We therefore explored whether the canine and human K_ATP channel

SUBMITTER: Vedovato N 

PROVIDER: S-EPMC12580652 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature