Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery.

ABSTRACT: Some nuclei of the hypothalamus are known for their important roles in maintaining energy homeostasis and regulating food intake. Moreover, obesity has been associated with hypothalamic inflammation and morphological alterations, as indicated by increased volume. However, the reversibility of these changes after bariatric surgery-induced weight loss remains underexplored. The aim of this study was to characterize volume changes in hypothalamic subunits up to 2 years following bariatric surgery. A secondary objective was to explore whether changes in hypothalamic subunit volumes were associated with changes in metabolic parameters and levels of gastrointestinal appetite-regulating hormones. Participants with severe obesity undergoing bariatric surgery were recruited. They completed high-res

SUBMITTER: Lachance A 

PROVIDER: S-EPMC12580804 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature