Impact of Population Cancer Risk on the Cost-effectiveness of Multicancer Early Detection Testing in the United States.

ABSTRACT:

Background

Cancer remains a significant global health challenge, particularly for subpopulations with risk factors including genetic predisposition, comorbidities, and lifestyle, along with age. The Galleri multicancer early detection (MCED) test is projected to be cost-effective for individuals ≥50 years of age. However, its potential value in subpopulations with elevated cancer risk remains underexplored. This study evaluates the cost-effectiveness (CE) of the Galleri test combined with usual care screening in subpopulations with varying cancer risk, including impact on overall cancer burden.

Methods

A hybrid cohort-level model evaluated US subpopulations of 50 to 79 years of age with additional risk factors, incorporating updated cancer incidence rates and excess competin

SUBMITTER: Raoof S 

PROVIDER: S-EPMC12580822 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature