Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer.

ABSTRACT:

Background

T-cell densities are associated with colorectal cancer outcome, but the significance of specific Th cell subsets is incompletely understood. We aimed to investigate the role of Th1 and Th2 cells and associated cytokine profiles.

Methods

We used multiplex IHC to identify Th1 and Th2 cells on tumor samples of more than 2,000 patients with colorectal cancer (three independent cohorts). We measured serum levels of Th1 and Th2 cytokines in mesenteric (N = 77) and peripheral (N = 603) blood samples. We evaluated the prognostic significance of Th1 and Th2 cells and their associations with circulating cytokines.

Results

High densities of both Th1 and Th2 cells were independently associated with better cancer-specific survival. In the largest cohort, the HR for high

SUBMITTER: Ojanpera A 

PROVIDER: S-EPMC12580825 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature