Integrative Transcriptomic Analysis Decodes the Interplay Between Aging, Senescence, and Cancer.

ABSTRACT: Cancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the comparative features of normal aging, cellular senescence, and cancer at single-cell resolution. By integrating analyses of genomics, epigenomics, and bulk and single-cell transcriptomics, we revealed a directionally opposite transcriptional profile between cellular senescence and tumorigenesis at the single-cell level, which may be affected by epigenomic regulations. A total of 648 aging-dependent senescence-associated coregulated modules (SACMs), disproportionately affecting the reproductive systems of both females and males, were initially defined across 17 t

SUBMITTER: Cai J 

PROVIDER: S-EPMC12580880 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature