Cerebellar White Matter Microstructure Is Associated With Age, Cerebrospinal Fluid Amyloid Beta Levels, and Cognition in Cognitively Unimpaired Older Adults.

ABSTRACT: Structural changes in the cerebellum contribute to cognitive decline due to aging and Alzheimer's disease (AD). However, it is unclear whether age and AD pathology are associated with structural alterations in the cerebellum among cognitively unimpaired individuals and how these alterations relate to cognition. This study examined the association of age and cerebrospinal fluid (CSF) AD biomarkers (amyloid beta [Aβ₄₂/Aβ₄₀], phosphorylated tau [p-tau₁₈₁]) with cerebellar gray matter (GM) and white matter (WM) volumes and cerebellar WM microstructure, measured via magnetic resonance imaging (MRI) among 176 cognitively unimpaired middle-aged and older adults (mean age = 66.70, range = 34-89). Cognition was measured with executive function and visuospatial compo

SUBMITTER: Paitel ER 

PROVIDER: S-EPMC12580907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature