Comparative safety and effectiveness of direct oral anticoagulants and warfarin in patients with venous thromboembolism in Finland, Norway and Sweden.

ABSTRACT: Aim: Clinical trial data have demonstrated that direct oral anticoagulants (DOACs) are both noninferior to and safer than conventional therapy for the treatment of venous thromboembolism (VTE). This study aimed to compare the effectiveness and safety of DOACs versus warfarin using Nordic population-based registries. Materials & methods: This observational cohort study used Swedish, Norwegian and Finnish national administrative data from 2012 to 2018. We identified treatment-naive adult patients with noncancer-related VTE treated with either a DOAC (apixaban or rivaroxaban) or warfarin. We employed inverse probability of treatment weighting for each DOAC-warfarin comparison and assessed the risks of bleeding (overall and by site: gastrointestinal bleeding [GI], intracranial bl

SUBMITTER: Ghanima W 

PROVIDER: S-EPMC12580917 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature