Blood neurofilament light chain as a predictive biomarker for functional outcome of acute ischemic stroke: a systematic review and meta-analysis.

ABSTRACT: Aim: Ischemic stroke continues to be a significant contributor to mortality and disability on a global scale. The blood neurofilament light chain (bNfL) as a prognostic indicator for stroke functional outcomes is a topic of ongoing debate. Thus, the objective of this systematic review is to assess the efficacy of bNfL as a predictor of stroke functional outcomes. Materials & methods: A systematic search was conducted in Pubmed, Cochrane and Embase databases from their inception to 21 October 2023. Two reviewers independently screened the search results to identify studies reporting on the association between bNfL and acute ischemic stroke outcomes. The quality of the studies was assessed using the Newcastle-Ottawa scale. Meta-analysis was conducted using the Comprehensive Met

SUBMITTER: Xu H 

PROVIDER: S-EPMC12580924 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature