Dynamic changes in chromatin accessibility and gene expression involved in fetal myogenesis of Min pigs.

ABSTRACT:

Objective

Chinese fat-type pig breeds possess good meat quality, but their growth rate and lean meat percentage are not dominant. Investigating the dynamic transcriptional regulation of skeletal muscle development could help improve meat yield in these breeds. However, little is known about chromatin accessibility and its association with gene expression during prenatal skeletal muscle development in these pigs.

Methods

ATAC-seq and RNA-seq were performed to profile chromatin accessibility and transcriptome in skeletal muscle at 45, 70, and 100 days post-coitus (E45, E75, and E100) from two male and two female full-sib fetuses of Min pig.

Results

This study demonstrated that the majority of ATAC-seq peak signals were located within 3 kb of transcription start sites. N

SUBMITTER: Hou X 

PROVIDER: S-EPMC12580940 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature