Effect of inhibiting prolactin secretion on secondary hair follicle development in cashmere goats.

ABSTRACT:

Objective

This study aims to investigate the molecular mechanisms by which inhibiting prolactin (PRL) secretion affects secondary hair follicle (SHF) development in cashmere goats.

Methods

A total of 20 cashmere goats were randomly assigned to either a bromocriptine (PRL inhibitor, BCT, 0.06 mg/kg BW) treatment (BCT+) or a control (BCT-) group. Blood and skin samples were collected monthly during telogen, and cashmere samples were collected after grow. Furthermore, the dermal papilla cells (DPCs) were isolated from SHF and cultured with PRL.

Results

The results showed that the percentage of active SHF in telogen decreased (p<0.05) in the BCT+ group. The inhibition of PRL secretion reduced (p<0.05) the serum PRL concentration, and the expression of the PRL, SPRLR, Kit,

SUBMITTER: Duan C 

PROVIDER: S-EPMC12580954 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature