Morphological and transcriptional insights into the role of histone phosphorylation-related genes in early development of the chicken duodenum.

ABSTRACT:

Objective

This study aimed to investigate the morphological transitions and the role of histone phosphorylation-related genes during the first week of duodenal development in broilers.

Methods

At hatch (D0) and 7 days post-hatch (D7), five broiler chickens were humanely euthanized and duodenal samples were collected to assess the histomorphology, specifically the duodenal villus height (VH), crypt depth (CD), and the VH/CD ratio. The gene expression data of duodenum of broilers at D0 and D7 obtained from the GEO database. Differentially expressed genes (DEG) analyses were conducted using GEO2R. In addition, histone phosphorylation-related genes were obtained from the GeneCards database. Function enrichment for DEGs was conducted using the DAVID and PANTHER databases. Hub gen

SUBMITTER: Li X 

PROVIDER: S-EPMC12580959 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature