Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization.

ABSTRACT: Amino acid derivatives of tert-leucine and phenyl glycine along with plant growth retardant and the precursor of fungicide paclobutrazol are deracemized by combining in situ electrochemical base generation to induce racemization and crystallization-induced chiral amplification in a one-pot, two-step deracemization procedure. Full enantioselective conversion (e.e. > 99%) of a mixture of enantiomers towards the desired handedness is achieved.

SUBMITTER: Leonard AS 

PROVIDER: S-EPMC12580979 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature